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Through analyzing the difference in level of plasma erythrocyte MPs in patients with acute coronary syndrome (ACS) and Stable Angina Pectoris (SAP),we could evaluate the association between erythrocyte MPs and ACS and SAP, meanwhile, to predict the value in diagnosis.
Among 1215 subjects who were enrolled, We identified 105 patients in whom ACS and 21 patients in whom stable angina Pectoris (SAP) were diagnosed through the collection of peripheral blood sample, 45 non-coronary artery disease (Non-CAD) who were enrolled as controls. The erythrocyte MPs were then separated by Ca2+ vector A23187 after precipitating the red blood cells (RBCs) by centrifugation. The erythrocyte MPs were labeled with a RBC specific antibody (glycophorine A), and subjected to high resolution flow cytometry for quantification.
The level of erythrocyte MPs in ACS group (27.1%±14.83%)were significantly higher than Non-CAD group(19.29%±16.54%) (P=0.005，P<0.05). AMI and UAP group versus Non-CAD (P=0.008,P=0.006). In the subgroup of ACS analyzing the difference was not statistically significant (P>0.05). The level of erythrocyte MPs in SAP group (41.58%±16.50%)was higher than non-CAD and ACS group (P=0.001，P=0.013), and was higher than the subgroup of ACS patients (P=0.011，P=0.040).
The level of erythrocyte MPs in ACS group were significantly higher, revealing erythrocyte MPs might play an important role during the development of ACS, having been associated with the acute cardiovascular events.