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Coronary heart disease (CHD) has become the major cause for human death. Previous studies have shown that early plaques can be regressed under the therapy of statins, while advanced plaques cannot. However, the response to the therapy of statin between early and advanced plaques in coronary heart disease patients was unknown. So the present study aims to explore whether the atherosclerosis plaques can be recovered under the therapy of statins in patients with CHD.
The present study evaluated the effect of 12 months statin therapy on early and advanced plaques in coronary heart disease patients by Intravascular Ultrasound (IVUS). 35 patients with 82 plaques were enrolled in the study including 25 early plaques and 57 advanced plaques. Early and advanced plaques were distinguished through coronary Optical Coherence Tomography (OCT).
There is not discrepancy between early and advanced plaques in total atherosclerosis volume, lumen volume, vessel volume at baseline and 12-month follow up for IVUS. However, the percent of atherosclerosis volume was lower in the group of early plaques compared with advanced plaques both at baseline and follow-ups. For the nominal and percent change from baseline to 12-month follow-ups, we did not find difference in total atherosclerosis volume, but the percent change of atherosclerosis volume was obviously different between the two groups.
The response to the therapy of statin was discrepant in early and advanced plaques. Early plaques can be recovered under the therapy of statin. However, advanced plaques show obvious resistance to statins.