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Jagged 1 on the surface of the endothelial cells has been reported that it can promote neovascularization. Previous studies have shown that neovascularization was associated with plaque vulnerability. However, there was no studies on the relationship between function of Jagged 1 and plaque vulnerability. This study aims to explore the relationship between the content of Jagged-1 in human blood mononuclear cells and plaque vulnerability.
We collected blood samples from 60 patients with acute coronary syndrome, who had OCT with three vessels. Then We extracted mononuclear cells from blood samples of these patients, and detecting the levels of Jagged1, as determined by western blot and RT-PCR. Samples can be divided into high level group and low level group, according to the levels of Jagged1. Then measure the indicators relating to plaque ulnerability of each sample, including TCFA, quantity of microchannel,lipid pool and macrophages, applying OCT measuring tool.
Patients clinical characteristics were comparable between the two groups. Compared with the low level of Jagged1 group, there was more lipid rich plaques in the high level of Jagged1 group (60.1% vs. 37.9%, P=0.003). Incidence of microchannels (80.1% vs. 20.9%, P=0.002), TCFA (76.3% vs. 30.2%, P=0.014) and macrophages (83.6% vs. 60.6%, P=0.037) was significantly higher in the high level group.
The present study reveals that the level of Jagged1 content was associated with plaque vulnerability in ACS patients.