Cardiac Effects of Highly Active Antiretroviral Therapy in Perinatally HIV-Infected Children
The CHAART-2 Study
Steven E. Lipshultz, James D. Wilkinson, Bruce Thompson, Irene Cheng, David A. Briston, William T. Shearer, E. John Orav, Joslyn A. Westphal, Tracie L. Miller, Steven D. Colan and for the CHAART-2 Investigator Group
Highly Active Antiretroviral Therapy-Associated Cardiac Changes in HIV-Infected Children
A comparison of longitudinal cardiac measurements of 74 highly active antiretroviral therapy (HAART)-exposed children from the CHAART (HAART-Associated Cardiotoxicity in HIV-Infected Children)-2 study and 140 HAART-unexposed children from the P2C2 HIV study cohort. During 11 years of follow-up, perinatally human immunodeficiency virus (HIV)-infected children exposed to HAART had consistently higher left ventricular (LV) fractional shortening and contractility while LV mass and end-diastolic septal thickness (ED SWT) were consistently lower when compared to a HAART-unexposed group.