Author + information
- Yong Hoon Kim1,
- Seung-Woon Rha2,
- Ae-Young Her3,
- Byoung Geol Choi2,
- Se Yeon Choi2,
- Jae Kyeong Byun2,
- Ahmed Mashaly4,
- Won Young Jang2,
- Woo Hyeun Kim2,
- Eun Jin Park2,
- Ja Yeon Choi2,
- Jin Oh Na2,
- Cheol Ung Choi2,
- Hong Euy Lim2,
- Eung Ju Kim2,
- Chang Gyu Park2,
- Hong-Seog Seo2 and
- Dong Joo Oh5
- 1Kangwon National University Hospital, Chuncheon, Korea, Republic of
- 2Korea University Guro Hospital, Seoul, Korea, Republic of
- 3Kangwon National University, Chuncheon, Korea, Republic of
- 4Korea University Guro Hospital, seoul, Korea, Republic of
- 5Korea university Guro Hospital, Seoul, Korea, Republic of
There are few clinical outcome data comparing 1st- versus 2nd-generation drug-eluting stents (DESs) in patients(pts) with acute myocardial infarction (AMI) who underwent successful percutaneous coronary intervention (PCI). We investigated the 3-year major clinical outcomes between 1st- versus 2nd-generation DESs in AMI pts.
A total of 883 AMI pts were enrolled. Pts were excluded if they had: (1) bare-metal stent or other types of DESs implantation, (2) balloon angioplasty alone, (3) incomplete or invalid data. Finally a total of 749 eligible AMI pts who underwent PCI with 1st-generation DESs (n = 386) or 2nd-generation DESs (n = 363) were enrolled. A propensity score matched (PSM) analysis was performed using the logistic regression model and 2-matched groups (273 pairs, n = 546, C-statistic = 0.729) were generated. Cumulative major adverse cardiac events (MACEs) up to 3 years were compared between the two groups.
During the 3-year follow-up period, the cumulative incidence of revascularization rates (TLR: hazard ration [HR], 2.40; 95% confidence interval [CI], 1.28-4,49; p = 0.006, TVR: HR, 2.24; 95% CI, 1.28-3.92; p = 0.005) and TLR-MACEs (HR, 1.87; 95% CI, 1.07-3.27; p = 0.029) and TVR-MACEs (HR, 1.68; 95% CI, 1.05-2.69; p = 0.031) were significantly higher in the 1st-generation DESs group compared with the 2nd-generation group after PSM.
During 3-year follow-up periods, 1st-generation DESs showed higher incidence of TLR, TVR, TLR-MACEs and TVR-MACEs rates in AMI pts who underwent successful PCI. However, the incidence of total death and MI were similar between the two groups.
CORONARY: Acute Myocardial Infarction