Author + information
- Saranapoom Klomjit1,
- Wasawat Vutthikraivit2,
- Subhanudh Thavaraputta3,
- Passisd Laoveeravat3,
- Sakolwan Suchartlikitwong2,
- Pakpoom Tantrachoti2,
- Pattara Rattanawong4 and
- Mohammad Ansari2
Atrial fibrillation(AF) has been known to increase complications after medical procedures. We aim to determine the effect of pre-existing atrial fibrillation on patients who underwent transcatheter aortic valve replacement (TAVR).
Databases were searched from inception through June 2017. The studies compared the risk of TAVR complications in pre-existing AF patients versus non-AF patients. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate pooled relative risks and 95% confidence intervals.
Nine studies from 2014 to 2017 involving total 4,788 TAVR patients, including 1,435 AF patients, were included in this meta-analysis. Compared with controls, pre-existing AF patients had a significantly higher mortality rate in overall analysis (pooled relative risk = 1.15, (1.10-1.21), I2=84.3%). Nevertheless, There is no significant difference in other complications including stroke and bleeding (pooled relative risk= 1.01 (0.95-1.06) and 1.02, (0.97-1.07) respectively).
Our study demonstrates a statistically significant increased mortality rate in AF population who underwent TAVR procedure. There is no significant difference in developing stroke and bleeding after TAVR in pre-existing AF and non-AF patients. This study suggests that pre-existing atrial fibrillation might be used as one of the pre-procedure characteristics to predict the adverse outcomes.
STRUCTURAL: Valvular Disease: Aortic