Author + information
- Brian Courtney1,
- Brian Li2,
- Natasha Alves-Kotzev2,
- Mark Harduar3,
- M. Saleem3,
- Jill Weyers2,
- Angela Kim2,
- Amandeep Thind4 and
- Jagdish Butany5
Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are widely used to image coronary arteries, plaque and devices, but are currently only available on separate catheters and systems. Hybrid IVUS OCT may facilitate a practical approach to collecting the high resolution and high-contrast images of OCT along with the deeper penetration depth of IVUS.
A 2.8F imaging system was developed that collects inherently co-registered 40 MHz IVUS and OCT images at up to 100 frames per second. Coronary arteries were harvested from formalin-fixed hearts at autopsy under an REB approved protocol and imaged via hybrid IVUS-OCT pullback. Histology was performed for comparison using H&E and Masson’s Trichrome staining. The system was also tested in vivo in porcine coronary arteries under an Animal Care Committee approved protocol.
Co-registered images of a range of pathologies were generated using IVUS, OCT and histology, including normal sections, deep and superficial calcifications, fibroatheromas with thin and thick caps, early-staged lesions and stent thrombosis. Pullback was performed in a porcine animal model, including the demonstration of stent malapposition. The left panel in the figure demonstrates an in vivo IVUS image of a stented artery, while the right panel is the corresponding OCT image. Both images were acquired simultaneously at the same cross-section.
In vivo imaging of coronary anatomy using a hybrid IVUS OCT catheter and system is feasible. Upcoming clinical investigations will assess the utility of this technology in assessing coronary anatomy, plaque characteristics and procedural results.
IMAGING: Imaging: Intravascular