Author + information
- Yanping Cheng1,
- Jenn McGregor1,
- Gerard Conditt1,
- Miguel Montero-Baker2,
- Greg Kaluza1 and
- Juan Granada1
Latest generation bare metal peripheral stents (BMS) have shown improved mechanically durability (fracture resistance) and expansion capabilities (lumen gain) following deployment in complex superficial femoral artery (SFA) lesions. The present study aimed to assess the acute device performance (lumen gain) and vascular response (neointimal proliferation) of 3 different SFA stent systems in spontaneously atherosclerotic, familial hypercholesterolemic swine (FHS).
Twenty-four iliofemoral arteries of 12 FHS were balloon-predilated on day 0 followed by implantation of a novel fluoropolymer-coated nitinol self-expanding paclitaxel-eluting stent (Eluvia, Boston Scientific), a helical interwoven nitinol wire stent (Supera, Abbott Vascular) and a conventional nitinol stent (EverFlex, Medtronic)(n=8 in each group). Angiography and optical coherence tomography (OCT) were scheduled for 30 and 90 days after treatment. This abstract presents the 30-day outcomes.
The degree of predilatation injury achieved in all groups was comparable at day 0 (balloon-to artery ratio: EverFlex=1.37±0.12, Supera=1.32±0.14, and Eluvia=1.41±0.09, p=0.39). Following stent implantation, there was no difference in the mean stent and minimal lumen areas among groups. OCT imaging at 30 days demonstrated smaller stent areas in Supera (19.08±0.87mm2) than Eluvia (23.15±1.88mm2) and EverFlex (21.97±1.99 mm2, p=0.001), while significantly lower % area stenosis was found in Eluvia (21±10%), than Supera (54±16%) and EverFlex (64±25%, p=0.0003). Mean neointimal thickness was also significantly lower in Eluvia (0.33±0.16mm) vs. Supera (0.87±0.33mm) and EverFlex (1.20±0.54mm, p=0.001). No total occlusion or stent fracture were observed in any implanted vessels.
When assessed by OCT after 30 days from implantation, Eluvia paclitaxel-eluting stent significantly contained neointimal proliferation in comparison to the Supera helical interwoven nitinol stent and conventional EverFlex nitinol stent in predilated femoral arteries of the FHS.
ENDOVASCULAR: Peripheral Vascular Disease and Intervention