Author + information
The aim of this study was to investigate association proteinuria and contrast induced nephropathy (CIN) in patients with acute coronary syndrome (ACS).
We evaluated 810 cases with ACS who undergoing primary percutaneous coronary intervention. CIN was defined as increase in serum creatinine ≧0.5mg/dl or ≧25% from baseline between 48 and 72hr.Dipstick urinalysis was performed with fresh spontaneously voided urine on admission. (-) and (±) were defined as proteinuria(-), and the rest were defined as proteinuria (+). Patients were stratified according to presence or absence of proteinuria and CIN.
We divided these cases into 4 groups. Group I : proteinuria (-) CIN (-) n=537, Group II : proteinuria (+) CIN (-) n=111, Group III proteinuria (-) CIN (+) n=90, Group IV: proteinuria (+) CIN (+) n=72. The patients with proteinuria and CIN were recognized in 8.9% of the patients with ACS. The ratio of Diabetes mellitus and Anemia in patients with proteinuria were higher than in patients without proteinuria.The kidney dysfunction was recognized at high rate in patients with proteinuria and cardiac dysfunction was recognized at high rate in patients with CIN. The mortality in patients with proteinuria was significantly higher than in patients without proteinuria among patients with CIN. The Kaplan-Meier survival curve was shown in the figure.
Combined CIN and proteinuria were associated with increased mortality in patients with ACS.
CORONARY: Acute Coronary Syndromes