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Little is known about etiology and clinical outcomes in primary takotsubo syndrome.
Patients with primary takotsubo syndrome were identified with International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis code 429.83 in Nationwide Readmission Databases (NRD). The primary outcome is all-cause readmission within 30 days after initial hospital. The secondary outcomes are readmissions for cardiac, heart failure and recurrence within 30 days after discharge. Univariate and multivariate logistic regression were performed to identify predictors of all-cause, cardiac, heart failure and recurrence readmission within 30 days after discharge.
10599 (national estimate=25553) patients were diagnosed with takotsubo syndrome as primary diagnosis from 2010 to 2014 in the United States. 105 patients were died during the initial hospitalization (in-hospital mortality=1.0%). Of the remaining (n=10494), 978 patients experienced all-cause readmission within 30-days after discharge (30-day all-cause readmission rate=9.3%). The most frequent cardiac cause of 30-day readmission was heart failure (9.9%), while respiratory failure was the leading non-cardiac cause (14.3%). Several variables in socioeconomic status, comorbidities, in-hospital treatment were identified as independent predictors for 30-day readmissions.
In-hospital mortality and thirty-day readmission rates were relatively low in primary takotsubo syndrome. Recognition of risk factors for short-term readmissions may lead to even better clinical management and outcomes.
CORONARY: Acute Coronary Syndromes