Author + information
- Chee Hae Kim1,
- Kyung Woo (KW) Park1,
- Jeehoon Kang1,
- Si-Hyuck Kang1,
- Jung-Kyu Han1,
- Han-Mo Yang2,
- Hyun-Jae Kang1,
- Bon-Kwon Koo1,
- Eun-Seok Shin3,
- Ju Hyeon Oh4,
- Sang-Hyun Kim5,
- Kyung-Kuk Hwang6,
- Keon Woong Moon7,
- Seung-Ho Hur8,
- In-Ho Chae9 and
- Hyo-Soo Kim1
- 1Seoul National University Hospital, Seoul, Korea, Republic of
- 2Seoul National University Hospital, seoul, Korea, Republic of
- 3Ulsan University Hospital, Ulsan, Korea, Republic of
- 4Samsung Changwon Hospital, changwon, Korea, Republic of
- 5Kyungpook National University, Daegu, Republic of Korea
- 6Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea
- 7Seoul, Korea, Republic of
- 8Keimyung University Dongsan Medical Center, Daegu, Korea, Republic of
- 9Seoul National University Bundang Hospital, Seonganmsi, Korea, Republic of
This study sought to compare long-term outcome of platinum chromium-based everolimus-eluting stents (PtCr-EES) versus cobalt chromium-based zotarolimus-eluting stents (CoCr-ZES) in all-comers receiving percutaneous coronary intervention.
3,755 patients receiving PCI were randomized 2:1 to PtCr-EES or CoCr-ZES, and 96.0% of patients completed 3-year clinical follow up. A dedicated angiographic follow-up was recommended between 12-15 months at the treating physicians’ discretion. The primary outcome was target lesion failure (TLF) at 3-year post-PCI, defined as the composite of cardiac death, target vessel-related myocardial infarction (MI), and ischemia-driven target lesion revascularization (TLR).
At 3 years, TLF occurred in 5.0% and 5.3% of the population in the PtCr-EES and CoCr-ZES groups, respectively (HR 0.962, 95% CI 0.714-1.296, p=0.992). There were no significant differences in the individual components of TLF. Dedicated angiography follow-up was performed in 38.9% of the total patients. In a landmark analysis of the subgroup that received angiographic follow-up, the TLF rate of the CoCr-ZES was significantly higher than PtCr-EES during the angiography follow-up period (p=0.009), mainly due to higher repeat revascularization rate.
PtCr-EES and CoCr-ZES showed comparable long-term outcomes. The rate of repeat revascularization in CoCr-ZES was higher than in PtCr-EES when dedicated angiography follow-up was performed, suggesting greater neointimal growth and higher late loss.
CORONARY: Stents: Drug-Eluting