Author + information
- Mariusz Tomaniak1,
- Cordula Felix2,
- Jiang Ming Fam3,
- Nicolas Van Mieghem4,
- Evelyn Regar5,
- Joost Daemen6,
- Jeroen Wilschut7,
- Peter P.T. De Jaegere8,
- Felix Zijlstra9,
- Yoshinobu Onuma4,
- Roberto Diletti2 and
- Robert-Jan van Geuns2
- 1Thorax Center, Erasmus MC, Department of Interventional Cardiology, Rotterdam, Netherlands, Medical University of Warsaw, First Department of Cardiology, Warsaw, Poland
- 2Thorax Center, Erasmus MC, Rotterdam, Netherlands
- 3Thorax Center, Erasmus MC; National Heart Centre Singapore, Rotterdam, Netherlands
- 4Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands
- 5University Heart Center, Universitätsspital Zürich, Zürich, Switzerland
- 6Erasmus MC - Thoraxcenter, United States
- 7Thoraxcenter Erasmus MC, Rotterdam, Netherlands
- 8Erasmus MC, Rotterdam, The Netherlands, Rotterdam, Netherlands
- 9Thoraxcenter, Erasmus Medical Centre, Rotterdam, Netherlands
Limited data are available on post-percutaneous coronary intervention (PCI) angina and quality of life after implantation of bioresorbable scaffold (BRS) among patients with complex lesions more reflective of real-world clinical practice.
This is a pooled analysis of BVS EXPAND and BVS STEMI Studies. Patients were prospectively evaluated using Seattle Angina Questionnaire (SAQ) and the EuroQol questionnaire (EQ-5D) at 1, 6, 12, 18 and 24 months after PCI. All five domains of SAQ (ranging 0 to 100, higher scores indicating better health status) and the EQ-5D Visual Analogue Scale (EQ VAS) score are reported.
A total of 347 patients [mean age 59.0±10.4, 74 % male; 34.6% STEMI, 27.7% non-STEMI, 10.7% unstable angina (UA), 21.7% stable angina (SAP)] was evaluated. At 1 month, 69.1% of patients were totally free from angina, with similar rates identified up to 24 months after PCI (table). At 1 month, the angina frequency score was 91±18 that also remained stable over two-year follow-up. On the other hand, a gain in physical limitation and EQ-5D VAS life quality scores between 30 days and 6 months was observed that persisted at consecutive time-points for EQ-5D VAS and reduced to original for SAQ physical limitation score. At 1 month STEMI patients were more often free of angina (table), as compared to NSTEMI and UA subgroup, which was consistent at further time-points. Also higher mean scores of angina frequency (94±10 vs 91±16, p=0.034), physical limitation (87±17 vs 80±20, p = 0.001) and EQ-5D VAS (78±13 vs 74±16, p = 0.029) were found in STEMI subjects.
|30 days||6 months||12 months||18 months||2 years|
|Angina free (overall)||69.1%||71.8%||65.4%||66.9%||67.3%|
|Angina frequency score||90.9 ± 17.8||92.9 ± 14.1||91.4 ± 15.2||92.2 ± 14.5†||92.5 ± 13.7|
|Physical limitation score||82.0 ± 20.9||84.9 ± 19.7||83.8 ± 20.4||81.5 ± 22.2||82.1 ± 21.5|
|EQ-5D VAS||73.7 ± 17.0†||78.1 ± 14.9‡||77.7 ± 15.6‡||76.3 ± 16.1||76.9 ± 16.3‡|
|Legends p < 0.05||‡ p < 0.05 vs. 30 days (paired analysis)||† p < 0.05 vs. 6 months (paired analysis)||* p < 0.05 vs. NSTEMI/UA /SA||§ p < 0.05 vs. NSTEMI/UA|
Implantation of BRS among patients with complex lesions was associated with good patient reported outcomes using SAE and EQ-5D. These results were comparable as reported for metallic stents. STEMI patients might achieve higher rates of freedom from post-PCI angina and superior EQ-5D VAS life quality scores.
CORONARY: Bioresorbable Vascular Scaffolds