Author + information
- Piotr Buszman1,
- Mateusz Kachel1,
- Carlos Fernandez2,
- Maciej Pruski Jr.1,
- Aleksandra Blachut3,
- Adam Janas4,
- Magdalena Michalak4,
- Paweł Buszman1 and
- Krzysztof Milewski1
- 1Center for Cardiovascular Research and Development, American Heart of Poland, Katowice, Poland
- 2Center for Cardiovascular Research and Development, American Heart of Poland, Katowice, Poland
- 3Center for Cardiovascular Research and Development American Heart of Poland, Katowice, Poland
- 4Center of Cardiovascular Research and Development, American Heart of Poland, Katowice, Poland
Treatment of long coronary lesions with bioresorbable scaffolds is currently limited to overlapping implantations only due to the lack of long devices. Additionally, vascular response to long versus regular scaffolds is unknown. Therefore, we compare long vs. regular scaffolds with 100 micrometer struts (MeRes100) in the porcine coronary restenosis model.
In total 35 scaffolds, including 23 regular (3.0 x 16 mm) and 12 long (3.0 x 33 mm) were implanted with 120% overstretch with optical coherence tomography (OCT) guidance in 12 domestic animals for 1, 7, 28, 90 and 180 days. At terminal follow-up, terminal imaging with OCT was performed and long scaffolds evaluated in pathology.
Stent areas and the neointimal hyperplasia as expressed as % Area Stenosis were comparable at all time points between long and regular scaffolds (Figure). Healing and endothelialisation were already complete at 28 days in the long scaffold group.
Implantation of long bioresorbable scaffolds was feasible. At mid-term their integrity remained intact and neointimal response comparable to regular size scaffolds, which is contrary to historical data with metallic stents.
CORONARY: Stents: Bioresorbable Vascular Scaffolds