Author + information
- Alessio La Manna1,
- Eligio Miccichè2,
- Guido D'Agosta2,
- Gabriel Tensol Rodrigues Pereira3,
- Guilherme F. Attizzani4,
- Piera Capranzano5,
- Davide Capodanno5 and
- Corrado Tamburino6
- 1University of Catania, Catania, Catania, Italy
- 2Ferrarotto Hospital, Catania, Catania, Italy
- 3University Hospitals - Harrington Heart & Vascular Institute, Cleveland, Ohio, United States
- 4University Hospital Harrington Heart & Vascular Institute, Cleveland, Ohio, United States
- 5Ferrarotto Hospital, Cardiology Division, University of Catania, Catania, Catania, Italy
- 6Ferrarotto Hospital, Cardiology Division, University of Catania, Catania, Italy
Bioresorbable vascular scaffold (BVS) have been heralded with many potential benefits which are especially desired in long lesions, including chronic total occlusion (CTO). The procedural feasibility and mid-terms outcomes of BVS in CTOs have been already tested, however there is still a paucity of data regarding the vascular response to BVS in CTO setting evaluated by optical coherence tomography (OCT).
This is a prospective study which included 21 Patients who had a CTO lesion treated with a BVS. After CTO recanalization and PCI, angiography and OCT scan were recorded at either baseline and scheduled 12-months follow-up. QCA in segment and in lesion analysis and OCT analysis evaluating qualitative and quantitative parameters, were performed by an independent core laboratory.
At 12-month angiographic follow-up, we observed a significant increase in the percentage of in-segment diameter stenosis (11.89±9.5% vs. 21.84±11.7%; p=0.002]. At OCT analysis there was a trend (p=0.07) towards increased mean scaffold area and significant reductions in mean lumen diameter (3.1±0.36 vs. 2.85±0.47; p=0.0046), mean lumen area (7.8±1.73 vs. 6.76±2; p=0.0082) and minimal lumen area (5.26±1.86 vs. 3.56±1.52; p<0.0001). Malapposition area and volume decreased from 0.26±0.17 to 0.08±0.1 (p=0.0003) and from 14.17±12.92 to 3.99±4.46 (p=0.0014). The mean malapposition lumen distance increased from 0.24±0.03 vs 0.37±0.21 (p=0.0093). Uncovered or malapposed struts decreased from 88.37%±11.66 to 5.29±6.48% (p<0.0001). The healing score at 12 months was 10.54±12.95.
In a small series of CTO patients treated with BVS implantation, OCT outcomes at 12 months were consistent with an overall favorable yet heterogeneous healing profile.
CORONARY: Stents: Bioresorbable Vascular Scaffolds