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Third generation biodegradable-polymer sirolimus-eluting stent (BP-SES, UltimasterTM stent) was expected to attain good arterial healing at chronic phase. We evaluated the arterial healing with angioscopy and optical coherence tomography (OCT).
In this multi-center prospective study, clinical outcome, follow-up angiography, angioscopy and OCT were evaluated at 10 months after implantation for 29 BP-SES in comparison with those for 31 permanent-polymer everolimus-eluting stent (PP-EES, XienceTM / PromusTM stent). By angioscopy, neointimal coverage (NIC) was graded into 4 groups (grade0: exposed, grade1: covered but bulging into lumen and visible, grade2: embedded but visible, grade3: invisible), and presence of intra-stent thrombus were also assessed. By OCT, the strut condition and thickness of neointima were evaluated.
The rate of target lesion revascularization was similar between two groups (3.4% in BS-SES vs 3.2% in PP-EES, p>0.99). In angioscopy evaluation, the average dominant NIC grade was significantly higher in BP-SES compared with PP-EES (Fig). The Frequency of intra-stent thrombus was significantly smaller in BP-SES group (14% vs 39%, p<0.05). In OCT evaluation, percentage of covered struts was greater in BP-SES group (99.4% vs 97.2%, p<0.05), while average neointimal thickness was similar between two groups (132 ﾎｼ m vs 120 ﾎｼ m, p=0.37).
BP-SES seemed to achieve better arterial healing at 10 months after implantation compared with PP-EES.
IMAGING: Imaging: Intravascular