Atrial Infarction and Ischemic Mitral Regurgitation Contribute to Post-MI Remodeling of the Left Atrium
Jaume Aguero, Carlos Galan-Arriola, Rodrigo Fernandez-Jimenez, Javier Sanchez-Gonzalez, Nina Ajmone, Victoria Delgado, Jorge Solis, Gonzalo J. Lopez, Antonio de Molina-Iracheta, Roger J. Hajjar, Jeroen J. Bax, Valentin Fuster and Borja Ibáñez
(A) Two models of ischemic mitral regurgitation were created by left circumflex (LCx) chronic occlusion according to: 1) the absence of additional occlusion of the left atrial main branch (LCx group); or 2) its presence (left atrial infarction [LAI] group). A model of infarction with no ischemic mitral regurgitation was created by left anterior descending artery (LAD) ischemia (LAD group 3). (B and C) Typical scar segmental distributions. (D) The timeline of imaging and histology evaluation. CMR = cardiac magnetic resonance.