Author + information
- Received October 5, 2017
- Revision received January 10, 2018
- Accepted January 10, 2018
- Published online March 5, 2018.
- aDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
- bCardiology Division, Massachusetts General Hospital, Boston, Massachusetts
- ↵∗Address for correspondence:
Dr. G. William Dec, Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Yawkey 5B, Boston, Massachusetts 01224.
Restrictive cardiomyopathies are the least common form of heart muscle disease. They are characterized as infiltrative and noninfiltrative, storage diseases, and endomyocardial disorders. Genetic diseases commonly present during childhood or adolescence. However, a growing percentage of elderly patients with heart failure with preserved ejection fraction are being recognized as having forms of restrictive cardiomyopathy, particularly cardiac amyloidosis. Noninvasive evaluation has replaced endomyocardial biopsy in the diagnostic evaluation of most suspected etiologies. The detection of infiltrative cardiomyopathies, including lysosomal and glycogen storage disorders, iron overload, and amyloidosis (both light chain amyloidosis and transthyretin amyloidosis variants), as well as inflammatory diseases such as sarcoidosis has slowly led to improved outcomes via disease-specific therapies.
Dr. Pereira is funded in part by the National Institute on Aging grant R21AG53512. Dr. Grogan has received consulting fees from Alnylam, Pfizer, and Prothena; and has received research support from Alnylam and Pfizer. Dr. Dec has reported that he has no relationships relevant to the contents of this paper to disclose. Robert James Siegel, MD, served as Guest Editor for this paper.
- Received October 5, 2017.
- Revision received January 10, 2018.
- Accepted January 10, 2018.
- 2018 American College of Cardiology Foundation
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