Author + information
- Peter Toth,
- Craig Granowitz,
- Michael Hull,
- Djibril Liassou,
- Amy Anderson and
- Sephy Philip
Low estimated glomerular filtration rate (eGFR) is associated with dyslipidemia and other CV risk factors and is an independent predictor of CV mortality. We analyzed real-world renal function data in high CV risk statin-treated patients with elevated triglycerides (TG).
Retrospective administrative claims study (Optum Research Database) of patients ≥45 years with diabetes and/or ASCVD without end-stage renal disease, hemodialysis or peritoneal dialysis with a statin prescription filled in 2010. A high-TG cohort (TG ≥150 mg/dL) and propensity-matched comparator cohort (TG <150 mg/dL, HDL-C >40 mg/dL) were assessed and followed for ≥6 months (or less due to death) to March 2016.
In the high-TG cohort vs the comparator cohort (both n=23,181), mean (SD) baseline eGFR was 90.1 (20.2) vs 90.7 (18.9) mL/min/1.73 m2 and mean (SD) follow-up was 41.4 (23.7) vs 42.5 (23.9) months. During >5 years of follow-up, the % of patients with eGFR <60 increased in both cohorts but was higher in the high-TG cohort at each time point; conversely, the % of patients with eGFR ≥90 decreased in both cohorts but was lower in the high-TG cohort at each time point (Figure). Differences between cohorts were not significant for the % of patients in each eGFR category but widened over time.
This real-world analysis of statin-treated patients with high CV risk suggests a trend toward greater worsening of renal function in patients with high TG vs patients without high TG over time.
Poster Hall, Hall A/B
Monday, March 12, 2018, 9:45 a.m.-10:30 a.m.
Session Title: Complex Patients and Comorbidities: Impact of Traditional Risk Factors
Abstract Category: 19. Interventional Cardiology: Complex Patients/Comorbidities
Presentation Number: 1290-304
- 2018 American College of Cardiology Foundation