Author + information
- Maria Chiara Palumbo,
- Francesco Bandera,
- Enrico Caiani,
- Eleonora Alfonzetti and
- Marco Guazzi
RV function is a major determinant of peak oxygen consumption (VO2) and exercise ventilation inefficiency as assessed by the rate of increase of ventilation (VE) over carbon dioxide production (VCO2). We aimed at defining the RV function determinants (preload, afterload and contractility) using 2D and 3D echocardiography, to detect their respective role in an impaired exercise performance.
109 consecutive patients referred for different cardiac diseases underwent cardiopulmonary exercise testing (CPET) combined with simultaneous 2D and 3D echocardiography. RV end diastolic volume (RVEDV) was considered a measure of preload. RV contractility was assessed by maximal elastance (Emax), assessed by PAPs over RV end systolic volume (RVESV). Afterload or arterial elastance Ea, was calculated as PAPs over RV stroke volume RVSV. RV function determinants were correlated to CPET variables.
Estimated preload did not correlate with CPET variables. Conversely, afterload showed a strong relation with the cardiopulmonary status of the patients with the closest correlations found for VE/VCO2 slope, O2 pulse peak, VD/VT peak and VO2 peak. Even with a weaker power of correlation, contractility was related to O2pulse peak, VD /VT% peak and VO2 peak. Results are shown in table 1.
Among the three determinants of RV systolic function, afterload is the one that best describes the aerobic performance and best predicts an impaired ventilatory efficiency.
|Preload r||p-value||Afterload r||p-value||Contractility r||p-value|
|VD /VT % rest||-0,057||0,572||0,134||0,180||0,244||0,013|
|VD /VT % peak||-0,129||0,188||0,593||0,000||0,383||0,000|
|O2 Pulse peak||0,182||0,060||-0,544||0,000||-0,468||0,000|
Poster Hall, Hall A/B
Saturday, March 10, 2018, 10:00 a.m.-10:45 a.m.
Session Title: Echocardiography in Evaluating Heart Failure
Abstract Category: 28. Non Invasive Imaging: Echo
Presentation Number: 1122-355
- 2018 American College of Cardiology Foundation