Author + information
- Colby Shanafelt,
- Vladimir Lakhter,
- Russell Rosenberg,
- Vikas Aggarwal,
- Paul Forfia,
- Anjali Vaidya,
- Chandra Dass,
- Huaqing Zhao,
- Yevgeniy Brailovsky,
- Farhan Raza and
- Riyaz Bashir
Catheter-directed thrombolysis (CDT) is being increasingly used in the management of acute submassive pulmonary embolism (PE). We sought to evaluate the pre and post-procedural echocardiographic and invasive hemodynamic parameters of patients with submassive PE treated with CDT.
We included all consecutive patients who underwent CDT for treatment of acute submassive PE between June 1st 2014 and September 1st 2017 in our cardiac catheterization lab. Both echocardiographic and invasive hemodynamic parameters were then assessed in this patient cohort before and after CDT. Independent sample t-test was used to compare means. Categorical variables were compared using the chi-square analysis.
A total of 49 patients underwent CDT during the study period. The patient cohort had an average mean arterial pressure of 90 mmHg, heart rate of 109 bpm, cardiac troponin I level of 0.67 ng/mL, and brain natriuretic peptide level of 376 pg/mL. There was a statistically significant improvement in both echocardiographic and invasive hemodynamic parameters following treatment with CDT (Table 1). There were no episodes of gastrointestinal bleeding or intracranial hemorrhage.
The results of our study indicate that the use of CDT in patients with submassive PE is safe and is associated with significant improvements in both invasive hemodynamic and echocardiographic parameters.
Moderated Poster Contributions
Vascular Medicine and Valvular Heart Disease Moderated Poster Theater, Poster Hall, Hall A/B
Sunday, March 11, 2018, 1:00 p.m.-1:10 p.m.
Session Title: The Clot Thickens: Advances in Venous Thromboembolism and Anticoagulation
Abstract Category: 39. Vascular Medicine: Endovascular Therapy
Presentation Number: 1231M-07
- 2018 American College of Cardiology Foundation