Author + information
- Ammar M. Killu,
- Mei Yang,
- Niyada Naksuk,
- Jason Tri,
- Scott Suddendorf,
- Samuel Asirvatham and
- Yong-Mei Cha
Vasovagal syncope (VVS) is the leading cause of syncope. The most frequent mechanism is that of a cardioinhibitory response, vasodepressor response, or mixture of both. Neural stimulation (stim) that negates the effects of vagal tone may be used as a treatment strategy for VVS.
Six male canines were studied. Stimulation (10-Hz, 2ms pulse duration, 2 mins stim duration) of the cervical vagus (CV), thoracic vagus (TV) and stellate ganglia (SG) was performed using needle electrodes at 3V, 5V & 10V output. SG stimulation overlaying TV was also performed where TV stimulation at 10V was performed with 10V SG stimulation being added. HR, BP & cardiac output (CO) were measured before, during & after stimulation.
In general, right vagal stim was associated with greater hemodynamic changes than left vagal stim. An output-dependent effect was observed with right CV & TV stim (panel A). Left & right SG stim significantly increased SBP, DBP & HR at 5V & 10V. The response was rapid (within 30 secs). An output-dependent increase in hemodynamic parameters was seen with both left & right SG stim. No difference between left & right SG stim was seen. SG stim overlay significantly increased HR& BP from baseline vagal stim bilaterally (panel B).
Stellate ganglia stimulation leads to increased HR and BP despite significant vagal stimulation. This may be exploited therapeutically in the management of vasovagal syncope.
Moderated Poster Contributions
Arrhythmias and Clinical EP Moderated Poster Theater, Poster Hall, Hall A/B
Saturday, March 10, 2018, 10:00 a.m.-10:10 a.m.
Session Title: New Insights Into Arrhythmias
Abstract Category: 06. Arrhythmias and Clinical EP: Other
Presentation Number: 1133M-03
- 2018 American College of Cardiology Foundation