Author + information
- Received December 10, 2017
- Revision received March 16, 2018
- Accepted April 9, 2018
- Published online June 11, 2018.
- Mohamad Alkhouli, MDa,b,∗ (, )@adnanalkhouli@MayoClinicCV@WestVirginiaU,
- Peter A. Noseworthy, MDa,c@noseworthypeter,
- Charanjit S. Rihal, MDc and
- David R. Holmes Jr., MDa
- aDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
- bDivision of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown, West Virginia
- cRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota
- ↵∗Address for correspondence:
Dr. Mohamad Alkhouli, Division of Cardiovascular Diseases, Department of Medicine, West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, West Virginia 26505-8059.
Ischemic stroke in patients with atrial fibrillation is associated with substantial morbidity and mortality. The growing epidemic of atrial fibrillation worldwide has raised concerns about the dire need for effective stroke prevention systems in these patients. Fortunately, the last decade has witnessed a plethora of data on novel stroke prevention methods in patients with nonvalvular atrial fibrillation. However, optimal selection and effective implementation of these preventative strategies require an integrative approach that takes into account not only the available clinical data but also the perspective of each of the stakeholders involved (patient, physician, and society). The goal of this review was to discuss the contemporary issues surrounding stroke prevention in atrial fibrillation from the perspective of these 3 major stakeholders.
- atrial fibrillation
- left atrial appendage
- non–vitamin K antagonist oral anticoagulant
- oral anticoagulation
- risk reduction
Dr. Holmes and the Mayo Clinic have a financial interest in technology related to this research (Watchman device); that technology has been licensed to Boston Scientific. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received December 10, 2017.
- Revision received March 16, 2018.
- Accepted April 9, 2018.
- 2018 American College of Cardiology Foundation
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