Author + information
- Received March 28, 2018
- Revision received June 12, 2018
- Accepted June 13, 2018
- Published online August 27, 2018.
- aInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas
- bDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
- ↵∗Address for correspondence:
Dr. Benjamin D. Levine, Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Dallas, Texas 75231.
Current guidelines recommend that patients with hypertrophic cardiomyopathy (HCM) not partake in high-intensity exercise due to the increased risk of sudden cardiac death. But individuals with genetic cardiomyopathies are not immune from cardiometabolic diseases, and inactivity is common in patients with HCM, likely due to fear of exercise-induced adverse events. The RESET-HCM trial (Study of Exercise Training in Hypertrophic Cardiomyopathy) illustrated that although moderate-intensity exercise may be safe in this population, the increase in cardiorespiratory fitness achieved with this training paradigm is modest. High-intensity exercise is an efficacious stimulus for increasing cardiorespiratory fitness in chronic disease populations. Such increases in fitness are associated with substantial reductions in cardiovascular mortality and may outweigh the theoretical risks associated with exercise in patients with HCM. The goal of this review is to examine the evidence supporting the safety and efficacy of different intensities of exercise training in HCM, and consider novel strategies to improve fitness.
Dr. Dias is supported by a Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center Fellowship. Biotronik has donated BioMonitor 2-AF Systems to the Dallas HIIT-HCM Pilot Study, at University of Texas Southwestern Medical Center, on which the authors are study investigators. The Dallas HIIT-HCM Pilot Study is supported by the Research Endowment from The American College of Sports Medicine Foundation awarded to Dr. Dias. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received March 28, 2018.
- Revision received June 12, 2018.
- Accepted June 13, 2018.
- 2018 American College of Cardiology Foundation
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