Author + information
- Received March 2, 2018
- Revision received July 17, 2018
- Accepted July 23, 2018
- Published online October 8, 2018.
- Wesley T. O’Neal, MD, MPHa,∗ (, )
- J’Neka S. Claxton, MPHb,
- Pratik B. Sandesara, MDa,
- Richard F. MacLehose, PhDc,
- Lin Y. Chen, MD, MSd,
- Lindsay G.S. Bengtson, PhDe,
- Alanna M. Chamberlain, PhDf,
- Faye L. Norby, MS, MPHc,
- Pamela L. Lutsey, PhDc and
- Alvaro Alonso, MD, PhDb
- aDepartment of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia
- bDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
- cDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota
- dCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota
- eHealth Economics and Outcomes Research, Life Sciences, Optum, Eden Prairie, Minnesota
- fDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
- ↵∗Address for correspondence:
Dr. Wesley T. O’Neal, Department of Medicine, Division of Cardiology, Emory University School of Medicine, 101 Woodruff Circle, Woodruff Memorial Building, Atlanta, Georgia 30322.
Background It is unknown whether early cardiology involvement shortly after atrial fibrillation (AF) diagnosis is associated with favorable outcomes in AF patients who have cancer.
Objectives The purpose of this study was to examine the relationship between early cardiology involvement after AF diagnosis in patients with history of cancer.
Methods This study examined associations of early cardiology involvement with oral anticoagulation use, stroke, and bleeding among nonvalvular AF patients (n = 388,045; mean age 68 ± 15 years; 59% male) with a history of cancer (past or active) from the MarketScan database (2009 to 2014). International Classification of Disease-9th Revision-Clinical Modification codes in any position were used to identify cancer diagnosis prior to AF diagnosis. Provider specialty and filled anticoagulant prescriptions 3 months prior to and 6 months after AF diagnosis were obtained. Poisson regression models were used to compute the probability of an oral anticoagulant prescription fill, and Cox regression was used to estimate the risks of stroke and major bleeding.
Results A total of 64,016 (17%) AF patients had a history of cancer. Cardiology involvement was less likely to occur among patients with a history of cancer than those without (relative risk [RR]: 0.92 [95% confidence interval (CI): 0.91 to 0.93]). Patients with history of cancer were less likely to fill prescriptions for anticoagulants (RR: 0.89 [95% CI: 0.88 to 0.90]) than those without cancer, and similar results were observed across cancer types. Patients with cancer were more likely to fill prescriptions for anticoagulants (RR: 1.48 [95% CI: 1.45 to 1.52]) if seen by a cardiologist. A reduced risk of stroke (hazard ratio: 0.89 [95% CI: 0.81 to 0.99]) was observed among all cancer patients who were seen by a cardiology provider, without an increased risk of bleeding (hazard ratio: 1.04 [95% CI: 0.95 to 1.13]). Similar results were observed when the analysis was stratified by active versus remote history of cancer.
Conclusions Although AF patients with cancer were less likely to see a cardiologist, or fill anticoagulant prescriptions, cardiology involvement was associated with increased anticoagulant prescription fills and favorable AF-related outcomes in AF patients with cancer.
Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award numbers R01-HL122200 and F32-HL134290; by the National Institute on Aging of the National Institutes of Health under award number R21-AG058445; and by the American Heart Association under award number 16EIA26410001. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the American Heart Association. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received March 2, 2018.
- Revision received July 17, 2018.
- Accepted July 23, 2018.
- 2018 American College of Cardiology Foundation
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