Author + information
- Received May 15, 2018
- Revision received July 5, 2018
- Accepted July 6, 2018
- Published online October 8, 2018.
- Horacio Medina de Chazal, MDa,b,
- Marco Giuseppe Del Buono, MDa,c,
- Lori Keyser-Marcus, PhDc,
- Liangsuo Ma, PhDd,
- F. Gerard Moeller, MDc,d,
- Daniel Berrocal, MD, PhDb and
- Antonio Abbate, MD, PhDa,c,∗ (, )@VCU@VCUMedResearch
- aVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
- bDepartment of Cardiology, Hospital Italiano, Buenos Aires, Argentina
- c‘Dianne and C. Kenneth Wright’ Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia
- dInstitute of Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia
- ↵∗Address for correspondence:
Dr. Antonio Abbate, VCU Pauley Heart Center, West Hospital, West Wing 5-020, 1200 East Broad Street, P.O. Box 980204, Richmond, Virginia 23298.
Stress cardiomyopathy is an acute reversible heart failure syndrome initially believed to represent a benign condition due to its self-limiting clinical course, but now recognized to be associated with a non-negligible rate of serious complications such as ventricular arrhythmias, systemic thromboembolism, and cardiogenic shock. Due to an increased awareness and recognition, the incidence of stress cardiomyopathy has been rising (15-30 cases per 100,000 per year), although the true incidence is unknown as the condition is likely underdiagnosed. Stress cardiomyopathy represents a form of neurocardiogenic myocardial stunning, and while the link between the brain and the heart is established, the exact pathophysiological mechanisms remain unclear. We herein review the proposed risk factors and triggers for the syndrome and discuss a practical approach to diagnosis and treatment of the patients with stress cardiomyopathy, highlighting potential challenges and unresolved questions.
Dr. Moeller has received grant funding from Indivior. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received May 15, 2018.
- Revision received July 5, 2018.
- Accepted July 6, 2018.
- 2018 American College of Cardiology Foundation
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