|First Author, Year (Ref. #)||Experimental AMI Model||Cardioprotective Agents or Interventions||Cardioprotective Effect||Timing of Intervention|
|Xin et al., 2010 (62)||In vivo rat||Limb RIPerC (4 × 5/5-min cycles)|
IPost (6 × 10/10-s cycles)
|Additive effects on reducing MI size, reducing ROS at reperfusion and inhibiting apoptosis||Ischemia—limb RIPerC|
Additive effects on Akt and Erk1/2 phosphorylation
|Yang et al., 2013 (44)||In vivo rat||Cangrelor at reperfusion|
Hypothermia (32°C–33°C) during ischemia
Cariporide during ischemia
|Additive effects of cangrelor combined with either cariporide or hypothermia on reducing MI size. Additive protection with all 3||Reperfusion—cangrelor, P2Y12 inhibitor|
Ischemia—hypothermia, reduces energy consumption
Ischemia—cariporide, Na+/H+ exchanger inhibitor
IPost = post-conditioning; ROS = reactive oxygen species; other abbreviations as in Table 1.
↵∗ Other criteria are as per Table 1.