Author + information
- Received February 21, 2017
- Revision received November 1, 2018
- Accepted November 5, 2018
- Published online March 11, 2019.
- Meredith Bryarly, MDa,∗,
- Lauren T. Phillips, MDa,∗,
- Qi Fu, MD, PhDb,c,
- Steven Vernino, MD, PhDa and
- Benjamin D. Levine, MDb,c,∗ (, )@texashealth
- aDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas
- bInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas
- cDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas
- ↵∗Address for correspondence:
Dr. Benjamin D. Levine, Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, 7232 Greenville Avenue, Suite 435, Dallas, Texas 75231.
Postural orthostatic tachycardia syndrome (POTS), the most common form of orthostatic intolerance in young people, affects approximately 500,000 people in the United States alone, typically young women at the peak of their education and the beginning of their working lives. This is a heterogeneous disorder, the pathophysiology and mechanisms of which are not well understood. There are multiple contributing factors and numerous potential mimics. This review details the most current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of POTS from cardiological and neurological perspectives.
↵∗ Drs. Bryarly and Phillips contributed equally to this work.
Dr. Fu was supported by a K23 grant (no. K23HL075283) from the National Institutes of Health (NIH). Dr. Bryarly has served on an advisory board for Biogen. Dr. Phillips has served as a consultant for ACI Clinical. Dr. Vernino has served as a consultant for Quest/Athena Diagnostics; and on an advisory board and Speakers Bureau for Lundbeck. Dr. Levine has served on the advisory board for Lundbeck; and has been a mentor on a K23 grant from the NIH.
Listen to this manuscript's audio summary by Editor-in-Chief Dr. Valentin Fuster on JACC.org.
- Received February 21, 2017.
- Revision received November 1, 2018.
- Accepted November 5, 2018.
- 2019 American College of Cardiology Foundation
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