Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair
Bartolo Ferraro, Giovanna Leoni, Rabea Hinkel, Steffen Ormanns, Nicole Paulin, Almudena Ortega-Gomez, Joana R. Viola, Renske de Jong, Dario Bongiovanni, Tarik Bozoglu, Sanne L. Maas, Michele D’Amico, Thorsten Kessler, Tanja Zeller, Michael Hristov, Chris Reutelingsperger, Hendrik B. Sager, Yvonne Döring, Matthias Nahrendorf, Christian Kupatt and Oliver Soehnlein
Annexin A1 Treatment Improves Cardiac Functionality by Driving Macrophage Polarization Toward a Pro-Angiogenic Phenotype
Cardiac repair after MI results from a finely orchestrated series of events, initiated after acute inflammation and immune cell infiltration that serve to digest and clear damaged cells and extracellular matrix. This phase is followed by a reparative phase with resolution of inflammation. Here, we show that myeloid cell-borne Annexin A1 shifts macrophage polarization toward a reparative, pro-angiogenic phenotype that ultimately enhances sprouting of new blood vessels through the release of vascular endothelial growth factor (VEGF)–A, hence improving cardiac functionality.