Author + information
- Pradyumna Agasthi,
- Justin Shipman,
- Reza Arsanjani,
- Moses Ashukem,
- Marlene E. Girardo,
- Charan Yerasi,
- Nithin R. Venepally,
- Floyd Fortuin and
- Farouk Mookadam
The objective of our study is to determine the effect of renal denervation (RDN) on blood pressure and renal function in patients with resistant hypertension (RH) in comparison to medical therapy alone.
We performed an extensive literature search for randomized control trials (RCT) reporting office and 24 hr. blood pressure changes and estimated glomerular filtration rate (eGFR) at baseline and 6 months. We calculated a weighted standardized mean difference of blood pressure and eGFR between RDN and control groups.
Our search yielded 608 studies of which we included 15 studies comprising 857 patients treated with RDN and 616 patients treated with medical therapy alone. Only 5 studies were double blinded RCT with sham control. The adjusted standardized mean difference in the change in office based systolic and diastolic pressures (p=0.18; p=0.14); 24 hr. systolic and diastolic pressures (p=0.20; p=0.18); and eGFR (p=0.20) from baseline to 6 months is statistically insignificant with significant heterogeneity. Subgroup analysis showed that among sham controlled trials, 24 hr. systolic blood pressure showed modest but statistically significant benefit favoring renal denervation in patients with RH.
Our meta-analysis of 15 RCTs showed no significant benefit of RDN on blood pressure control in patients with resistant hypertension. Subgroup analysis of sham control studies showed a modest benefit in 24 hr. systolic blood pressure at 6 months with RDN.
Poster Hall, Hall F
Saturday, March 16, 2019, 3:45 p.m.-4:30 p.m.
Session Title: Interventional Cardiology: Carotid and Endovascular Intervention 1
Abstract Category: 18. Interventional Cardiology: Carotid and Endovascular Intervention
Presentation Number: 1150-004
- 2019 American College of Cardiology Foundation