Author + information
- Sarah Leatherman,
- Ryan Ferguson,
- Isabelle Weir,
- Cynthia Hau,
- Craig Granowitz,
- Kelly Harrington,
- Sephy Philip,
- Peter Toth,
- Deepak L. Bhatt and
- William Boden
Recent studies have suggested a causal role for elevated triglycerides (TG) in incident cardiovascular (CV) events. Using a large cohort of U.S. veterans with statin-controlled LDL-C levels (40-100mg/dL), we explored whether increased residual CV risk existed in patients with elevated baseline TG levels versus those with normal TG levels.
We identified veterans receiving a statin but not a TG-lowering agent from the VA Corporate Data Warehouse, a database of the VA electronic health record, from 2010-2015. We compared CV event rates (nonfatal MI, stroke, unstable angina, or coronary revascularization) between the elevated TG (150-500mg/dL) and normal TG (<150mg/dL) groups. We calculated crude event rates, rate ratios, and 95% CI for both groups, and adjusted event rate ratios for baseline blood pressure, HbA1C, glomerular filtration rate, and HDL-C.
We included 439,019 veterans (predominantly male and white) in the analysis cohort of whom 132,203 (30%) had elevated TG levels. These subjects were younger and had higher BMIs. Table 1 details the comparative baseline data and CV event rates. The overall crude and adjusted CV event rate ratios were 1.37 (95% CI 1.34,1.40; P<0.001) and 1.19 (95% CI 1.16, 1.22; P<0.001), respectively.
In this large cohort of veterans, those with elevated TG levels showed a significant increase in CV events despite well-controlled LDL-C on statins and adjustment for HDL-C compared to veterans whose baseline TG was in a normal range.
Moderated Poster Contributions
Prevention Moderated Poster Theater, Poster Hall, Hall F
Monday, March 18, 2019, 1:15 p.m.-1:25 p.m.
Session Title: Novel Risk Markers and Cardiovascular Disease Events
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1060-09
- 2019 American College of Cardiology Foundation