Author + information
- Cameron Lambert,
- Scott Anjewierden,
- David Majdalany,
- Elizabeth Saarel and
- Peter Aziz
Congenital heart disease (CHD) affects nearly 1% of persons. With advances in surgical technique, many patients live well into their adult years but may develop cardiac dysfunction. Often, this dysfunction is related to ventricular dyssynchrony. The goal of this study was to assess whether CHD patients can benefit from cardiac resynchronization therapy (CRT) and whether this is a feasible and safe therapy for this unique population.
All patients with a history of CHD who received CRT at our center were analyzed in this study. Clinical information was obtained by chart review and analyzed by the authors.
Since 1999, 36 CHD patients received CRT. CHD diagnoses included left sided obstruction (N=14), transposition of the great vessels (N=7), tetralogy of Fallot (N=4) and atrioventricular canal defects (N=6). Six patients with transposition of the great vessels had a systemic right ventricle. Figure 1 details the baseline demographics for our population, characteristics of responders (EF improvement by at least 5%) and nonresponders. CRT significantly improved NYHA functional class and systemic ventricle ejection fraction.
CRT is effective and yields significant improvements in symptom burden and EF. Changes in QRS duration do not predict symptom improvement. Implantation of CRT in CHD patients has a higher rate of complications than in structurally normal hearts. Further analysis will be directed towards understanding predictors for CRT response.
Poster Hall, Hall F
Saturday, March 16, 2019, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias and Clinical EP: Devices 2
Abstract Category: 05. Arrhythmias and Clinical EP: Devices
Presentation Number: 1170-285
- 2019 American College of Cardiology Foundation