Author + information
- Yuko S. Soyama,
- Nobuyuki Kagiyama,
- Masataka Sugahara,
- Justin Vader and
- John Gorcsan
Vector flow mapping (VFM) can quantify left ventricular (LV) flow mechanics noninvasively. VFM can measure LV energy loss and pump efficiency. However, the association of LV energy loss to symptom severity and serum biomarkers in heart failure patients with reduced ejection fraction (HFrEF) is unknown.
We studied 77 subjects; 38 with HFrEF and 39 controls (PROSOUND F75 Premier CV, Hitachi Corp.). Energy loss time integrals were assessed using VFM as a total energy loss during the cardiac cycle. Routine measures (including EF) and global longitudinal strain (GLS) were recorded. We compared LV energy loss to NYHA functional class and serum biomarker N-terminal pro B-type natriuretic peptide (NT-proBNP) levels in HFrEF patients.
HFrEF patients were different from normal controls as expected: EF 23.7±12.3% vs. 66.5±4.7% and GLS 5.4±1.9% vs. 18.5±1.4% and energy loss 7.8±2.2 cJ vs. 4.1±2.1, respectively (all p<0.01). In HFrEF patients, group mean NT-proBNP was 9903±2007 pg/ml. HFrEF patients were grouped by energy loss tertiles. LV energy loss time integrals were significantly associated with increases in NT-pro BNP levels and NYHA class (p=0.03 and 0.04, respectively). Interestingly, LV energy loss was more significantly correlated with NYHA functional class and NT-pro BNP levels than LVEF and GLS.
LV energy loss by VFM was significantly and linearly associated with symptom severity and serum biomarkers in HFrEF patients and has potential for clinical utility.
Poster Hall, Hall F
Saturday, March 16, 2019, 3:45 p.m.-4:30 p.m.
Session Title: Heart Failure and Cardiomyopathies: Clinical 2
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1186-507
- 2019 American College of Cardiology Foundation