Author + information
- Ali Alkhayru,
- Bassman Tappuni,
- Belal Kaseer,
- Freidoon Ghazi,
- John Wilson,
- Kathleen Smith,
- William Schnettler,
- Jenni Steinbrunner and
- Kamal Shemisa
Pregnancy related heart disease is prevalent & exhibits significant morbidity. Peripartum Cardiomyopathy (PPCM) & Preeclampsia (PE) are 2 conditions with significant overlap. We sought to determine clinical risk factors of PPCM versus PE.
A retrospective case control study was undertaken using our EMR database from 2013-2018 in two centers. Clinical characteristics of 27 PPCM were compared to an age/BMI matched cohort of 81 PE patients. Statistical analysis was done by student's t-test, chi-square & Wilcoxon rank sum. A p value of <0.05 was considered significant.
The PPCM & PE data are reported in table 1. The mean left ventricular ejection fraction & median BNP for PPCM was 44.7±14.4% & 441 (83.8-844.8) pg/ml respectively. Median systolic & diastolic blood pressures at the time of diagnosis were similar. Median gestational age & birth weights were higher in the PPCM cohort. Pre-existing hypertension & smoking were associated with PPCM; (OR-2.89, p-0.04), (OR-3.5, P-0.03). Hyponatremia & proteinuria were associated with PE; (OR-0.11, p-0.02), (OR-0.18, p-0.008).
Patients affected by PPCM and PE share similar demographics & baseline blood pressures. Low birth weight & early gestational age likely represent the clinical course & management of PE. Hypertension and smoking were associated with PPCM whereas hyponatremia and proteinuria were associated with PE. Whether treatment of hypertension and smoking cessation modifies risk for PPCM is unknown at this time.
Poster Hall, Hall F
Saturday, March 16, 2019, 3:45 p.m.-4:30 p.m.
Session Title: Heart Failure and Cardiomyopathies: Clinical 2
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1186-553
- 2019 American College of Cardiology Foundation