Author + information
- Seamus P. Whelton,
- Paul McAuley,
- Olusola Orimoloye,
- Erin Michos,
- Clinton Brawner,
- Jonathan Ehrman,
- Steven Keteyian,
- Mouaz Al-Mallah and
- Michael Blaha
Traditional cardiovascular disease (CVD) risk factors have a decreased predictive strength with increasing age. We sought to determine if fitness could improve risk stratification among older adults at the extremes of CVD risk factor burden.
We studied 6,509 patients ≥70 years of age without CVD from the Henry Ford Exercise Testing Project (FIT Project). Patients underwent a physician referred treadmill stress test with fitness grouped as <6, 6-9.9, and ≥10 METs. Traditional CVD risk factors (hypertension, hyperlipidemia, diabetes, and smoking) were summed from 0 to ≥3. We calculated adjusted Cox hazard models and Kaplan-Meier survival graphs.
Patients had a mean age of 74.5 ±4 years (52% women) and there were 2,526 deaths over a mean 9.4 ±4.4 years follow-up. The mortality rate per 1,000 person years was approximately 55 for the least fit (<6 METs) and 25 for the most fit (≥10 METs) regardless of the number of risk factors. A higher fitness (A), but not lower number of risk factors (B), was associated with improved survival (Figure). In adjusted Cox models, older persons with ≥3 risk factors who had moderate (6-9.9 METs) and high (≥10 METs) fitness had a reduced mortality hazard of 0.64 (95% CI 0.54-0.76) and 0.47 (95% CI 0.36-0.62), respectively, when compared to the least fit.
Among adults aged ≥70, there was no difference in survival between patients with 0 or ≥3 CVD risk factors, but higher fitness was associated with improved survival regardless of CVD risk factor burden.
Poster Hall, Hall F
Saturday, March 16, 2019, 10:00 a.m.-10:45 a.m.
Session Title: Non Invasive Imaging: Sports and Exercise 1
Abstract Category: 31. Non Invasive Imaging: Sports and Exercise
Presentation Number: 1126-336
- 2019 American College of Cardiology Foundation