Lipid Accumulation in Hearts Transplanted From Nondiabetic Donors to Diabetic Recipients
Raffaele Marfella, Cristiano Amarelli, Francesco Cacciatore, Maria Luisa Balestrieri, Gelsomina Mansueto, Nunzia D’Onofrio, Salvatore Esposito, Irene Mattucci, Gemma Salerno, Marisa De Feo, Michele D’Amico, Paolo Golino, Ciro Maiello, Giuseppe Paolisso and Claudio Napoli
Lipid Accumulation in Hearts Transplanted from Nondiabetic Donors to Diabetic Recipients: Study Protocol
Unique real-life study showing the role of myocardial lipid accumulation in early events of human diabetic cardiomyopathy. Diabetic-related insulin resistance, peroxisome proliferator-activated receptor (PPAR) system leads to increased myocardial triglyceride accumulation with subsequent early impairment of cardiac function. Metformin blunts lipid accumulation and PPAR involvement in diabetic recipients.