Author + information
- Nina Rashedi,
- Luis Landeras,
- Victor Mor-Avi,
- Davide Genovese,
- Peng Lai,
- Wang Haonan,
- Kalie Kebed,
- Isla McClelland,
- Anja Brau,
- Martin Janich,
- Roberto Lang and
- Amit R. Patel
4D-flow is a cardiac magnetic resonance technique which allows quantification of blood flow in 3-dimensional space; however, adequate image quality requires the use of contrast agents. We developed a new 4D-flow approach (multiple overlapping thin slabs (MOTS)) capable of generating sufficient signal without the need for a contrast agent. We hypothesize that MOTS would result in an improved ability to measure aortic flow compared to the currently available non-contrast 4D-flow technique.
We prospectively studied aortic flow in 19 patients with 2D-phase contrast (2D-PC) imaging and three 4D-flow techniques (conventional acquisitions pre- and post-contrast and a non-contrast MOTS). Imaging was performed on a 3T scanner. The ability to quantify flow through the aortic valve was determined for each of the 4D-flow sequences and compared against the reference standard of 2D-PC using Arterys software.
Aortic flow measurements were possible in 53% and 95% patients using the pre- and post-contrast standard acquisitions, respectively, and in 89% using MOTS (figure). The correlation between pre-contrast 4D-flow measurements and 2D-PC was weak (r=0.21) but improved significantly with contrast enhancement (r=0.71) and MOTS (r=0.67).
Relative to the standard non-contrast 4D-flow technique, non-contrast MOTS significantly improves the feasibility and accuracy of quantifying blood flow through the aortic valve to a degree similar to contrast enhanced 4D-flow.
Posters Hall_Hall A
Sunday, March 29, 2020, 10:00 a.m.-10:45 a.m.
Session Title: Non Invasive Imaging: MR 4
Abstract Category: 29. Non Invasive Imaging: MR
Presentation Number: 1261-157
- 2020 American College of Cardiology Foundation