Author + information
- Xiaoxiao Guo,
- Yongfa Huang and
- Huazhen Liu
Cardiac involvement is one of the major causes of death in polymyositis (PM) and dermatomyositis (DM). Here, we investigated prognostic factors for death and cardiac events in PM/DM patients with cardiac involvement (PM/DM-CI).
We retrospectively reviewed clinical manifestations, cardiac characteristics, and outcomes in PM/DM-CI patients. The composite endpoint included death from any cause, and rehospitalization for heart failure, cardiac arrest or cardiogenic shock. Survival analysis was based on Cox regression using Efron method and likelihood ratio test.
Of 79 PM/DM-CI patients (35 male, median age at onset 47 years), 28 patients met the composite endpoint within 3 years from the diagnosis. Cardiac manifestations included new onset of myocardial injury, cardiac dysfunction, arrhythmias, valvular abnormality and pericardial effusion. Independent prognostic factors for composite endpoint included ventricular arrhythmia (hazard ratio [HR] 2.359, P = 0.036), moderate to severe valvular regurgitation (HR 2.942, P = 0.012) and peak cardiac troponin I (cTnI) > 0.699 µg/L (HR 2.914, P = 0.012). Ventricular arrhythmia was more common in PM than DM, and associated with longer disease duration, milder inflammation and positive anti-mitochondrial antibody (AMA).
Ventricular arrhythmia, valvular regurgitation and elevated cTnI are independent prognostic factors in PM/DM-CI. AMA could serve as a biomarker for ventricular arrhythmia in PM/DM-CI.
Posters Hall_Hall A
Sunday, March 29, 2020, 10:00 a.m.-10:45 a.m.
Session Title: Heart Failure and Cardiomyopathies: Clinical 4
Abstract Category: 13. Heart Failure and Cardiomyopathies: Clinical
Presentation Number: 1260-080
- 2020 American College of Cardiology Foundation