Author + information
- Received August 30, 1985
- Revision received March 26, 1986
- Accepted April 2, 1986
- Published online September 1, 1986.
- Raimund Erbel, MD*,1,
- Tiberius Pop, MD1,
- Karl-Jürgen Henrichs, MD1,
- Klaus von Olshausen, MD1,
- Carl J. Schuster, MD1,
- Hans-Jürgen Rupprecht, MD1,
- Claus Steuernagel, Cand Med1 and
- Jürgen Meyer, MD1
- ↵*Address for reprints: Raimund Erbel, MD, II. Medical Clinic, Johannes Gutenberg University, Langenbeckstrasse 1, D-6500 Mainz, West Germany 06131-17-3273.
In 162 patients with acute transmural myocardial infarction, combined intravenous and intracoronary thrombolytic therapy with streptokinase was initiated. In vessels that remained occluded, mechanical recanal-ization was performed with a 3F recanalization catheter (group I, n = 79) or a 4F Grüntzig balloon catheter (group II, n = 83). After reperfusion, intracoronary streptokinase was administered superselectively. After termination of streptokinase infusion, angioplasty was performed only in patients in group II. There was no difference between the groups in relation to sex, age, infarct location, creatine kinase levels and time between onset of symptoms and start of treatment. Initial coronary angiography showed an open vessel in 27 (34%) of 79 patients in group I and 21 (25%) of 83 patients in group II. The final reperfusion rate was 90% (71 of 79) in group I and 86% (71 of 83) in group II. Angioplasty was attempted in 69 of the 71 patients in group II with a success rate of 65% and an occlusion rate of 3%.
During the hospital stay, reocclusion occurred in 14 (20%) of 71 patients in group I. After thrombolytic therapy, coronary luminal narrowing in group I was 75 ± 17% in patients without and 87 ± 6% in patients with reocclusion (p < 0.05). In group II, reocclusion was found in 10 (14%) of 71 patients. After angioplasty, the degree of coronary stenosis in group II was reduced from 82 ± 12 to 51 ± 30% (p < 0.001). Reocclusion was found in 3 (7%) of the 45 patients with successful angioplasty and in 7 (32%) of the 22 patients with unsuccessful angioplasty (p < 0.01). Improvement in regional left ventricular function was observed only in patients from group II with anterior myocardial infarction.
In conclusion, by combined medical and mechanical recanalization, the rate of coronary reperfusion can be increased and infarct time shortened, providing the possibility of full revascularization by angioplasty, with improvement of regional wall motion and reduction of the rate of reocclusion.
- Received August 30, 1985.
- Revision received March 26, 1986.
- Accepted April 2, 1986.
- American College of Cardiology Foundation