Author + information
- Received February 10, 1986
- Revision received April 1, 1986
- Accepted April 4, 1986
- Published online November 1, 1986.
- Robert C. Wesley Jr., MD1,*,2,
- Bruce B. Lerman, MD1,3,
- John P. DiMarco, MD, PhD, FACC1,
- Robert M. Berne, MD1 and
- Luiz Belardinelli, MD1,4
- ↵*Address for reprints: Robert C. Wesley, Jr., MD, Box 500, University of Virginia Medical Center, Charlottesville, Virginia 22908.
Mechanisms responsible for atrioventricular (AV) block during acute inferior myocardial infarction are only partially understood. Increased parasympathetic tone is the factor usually postulated; however, persistence of AV block after atropine administration is frequently observed. Adenosine, an endogenous ischemic metabolite, has well established depressant effects on AV node con- auction. In this report, an episode of atropine-resistant AV block was reversed by aminophylline, a competitive adenosine antagonist, in a patient with an acute inferior myocardial infarction. This observation suggests a role for adenosine in the mediation of ischemia-induced AV node block.
- Received February 10, 1986.
- Revision received April 1, 1986.
- Accepted April 4, 1986.
- American College of Cardiology Foundation