Author + information
- Received August 11, 1986
- Revision received October 1, 1986
- Accepted October 17, 1986
- Published online March 1, 1987.
- Denis Roy, MD, FACC*,1,
- François Paillard, MD1,
- Dennis Cassidy, MD1,
- Martial G. Bourassa, MD, FACC1,
- Jolanta Gutkowska, PhD1,
- Jacques Genest, OC, MD1 and
- Marc Cantin, MD, PhD1
- ↵*Address for reprints: Denis Roy, MD, Montreal Heart Institute, 5000 East Belanger Street. Montreal, Quebec HIT 1C8, Canada.
Plasma immunoreactive atrial natriuretic factor was measured in 10 patients with chronic atrial fibrillation before and after cardioversion to sinus rhythm, and in 14 patients during electrophysiologic evaluation of paroxysmal supraventricular tachycardia. The mean plasma concentration of atrial natriuretic factor in atrial fibrillation was 138 ± 48 pg/ml and decreased to 116 ± 45 pg/ml 1 hour after cardioversion to sinus rhythm (p < 0.005). The mean plasma concentration of atrial natriuretic factor increased from 117 ± 53 pg/ml in sinus rhythm to 251 ± 137 pg/ml during laboratory-induced supraventricular tachycardia (p < 0.005). Right atrial pressures were recorded in 12 patients; the baseline atrial pressure was 4.3 ± 1.9 mm Hg and increased to 7.4 ± 3.6 mm Hg during supraventricular tachycardia (p < 0.005). A modest but significant linear relation was noted between the changes in plasma atrial natriuretic factor and right atrial pressure measurements during induced supraventricular tachycardia (r = 0.60, p < 0.05).
In conclusion, changes in atrial rhythm and pressure may be an important factor modulating the release of atrial natriuretic factor in the circulation and raised levels of this hormone may be a contributing factor for the polyuria and the hypotension associated with paroxysmal supraventricular tachyarrhythmias.
- Received August 11, 1986.
- Revision received October 1, 1986.
- Accepted October 17, 1986.
- American College of Cardiology Foundation