Author + information
- Received August 8, 1986
- Revision received October 21, 1986
- Accepted January 14, 1987
- Published online June 1, 1987.
- Rohit R. Arora, MD*,‡,
- Josef Machac, MD*,
- Martin E. Goldman, MD, FACC*,
- Robert N. Butler, MD†,
- Richard Gorlin, MD, FACC* and
- Steven F. Horowitz, MD, FACC*
- ↵‡Address for reprints: Rohit R. Arora, MD, Montefiore Hospital, Division of Cardiology, 111 East 210 Street, Bronx, New York 10467.
A delay of left ventricular isovolumic relaxation and decrease in myocardial compliance may result in a decline of measured early filling rates in elderly subjects. Previous studies of diastolic function, however, have not excluded coronary artery disease or addressed the contribution of atrial contraction to diastole-The present study evaluated radionuclide-derived diastolic variables in 13 healthy elderly volunteers aged 75 ± 6 years without symptoms or risk factors for coronary disease who had normal findings on the stress electrocardiogram, stress gated blood pool imaging and two-dimensional echocardiogram. Results were compared with those of a group of 10 healthy young volunteers aged 26 ± 5 years. High count, 32 frame, double-buffered gated blood pool acquisitions were obtained at rest in the left anterior oblique view with an RR interval variation <5%. Left ventricular time-activity curves were analyzed and flow-volume loops for each group were constructed.
In the healthy elderly: 1) peak early diastolic filling rate is decreased, 2) time of peak early filling and time to first third of diastolic filling are delayed, and 3) peak late left ventricular filling rate and percent of atrial filling volume are augmented, suggesting an adaptive response of the atria to diminished left ventricular compliance.
- Received August 8, 1986.
- Revision received October 21, 1986.
- Accepted January 14, 1987.
- American College of Cardiology Foundation