The sodium-glucose co-transporter 2 (SGLT2) is located in the initial convoluted portion (S1 segment) of the proximal tubule and accounts for 90% of the reabsorbed glucose. Residual glucose is reabsorbed by the sodium-glucose co-transporter 1, in the distal end of the convoluted tubule (S2/S3 segments) of the proximal tubule. (Inset) Sodium-glucose co-transporters drive the sodium (Na+)-coupled glucose entry against the concentration gradient across the apical membrane. Na+ is maintained at a very low intracellular concentration by a basolateral Na+/potassium (K+)-adenosine triphosphatase (ATPase), an energy-dependent pump that pumps K+ into the cell and Na+ out of the cell. Glucose leaves the cell down its concentration gradient into the blood through facilitative glucose transporters (GLUT2). DCT = distal convoluted tubule; PCT = proximal convoluted tubule.