Author + information
- Received February 19, 2019
- Revision received March 21, 2019
- Accepted March 24, 2019
- Published online May 3, 2019.
- Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom
- ↵∗Address for correspondence:
Dr. Stuart J. Pocock, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.
• This review is a constructive critical appraisal of key recent cardiology trial reports.
• The trials are CABANA, ATTR-ACT, COAPT, DECLARE, REDUCE-IT, and AUGUSTUS.
• For each study, the main findings are documented and interpreted.
• Particular attention is paid to new findings, their research context, and study limitations.
• Topical examples provide methodological insights pertinent to future clinical trials research.
In the past 12 months, many important new clinical trials in cardiology have had their first conference presentation and publication. This paper presents a constructive critical appraisal of 6 key studies. In time order of first presentation, they are CABANA, ATTR-ACT, COAPT, DECLARE, REDUCE-IT, and AUGUSTUS. For each study, the aim herein is to document and interpret the main findings, paying attention to new findings, their research context, and study limitations. These topical examples also provide methodological insights pertinent to future clinical trials research.
Dr. Pocock has served on Steering Committees or Data Monitoring Committees for trials sponsored by Abbott Vascular, Amirin, AstraZeneca, Bayer, Biosensors, Boehringer Ingelheim, Boston Scientific, Bristol-Myers Squibb, Edwards Lifesciences, Idorsia, Medtronic, Novartis, and Vifor. Dr. Collier has served on Data Monitoring Committees sponsored by AstraZeneca, Boston Scientific, Daiichi-Sankyo, Devax, Infraredx, Medtronic, Pfizer, and Zoll.
- Received February 19, 2019.
- Revision received March 21, 2019.
- Accepted March 24, 2019.
- 2019 American College of Cardiology Foundation
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