RT Journal Article
SR Electronic
T1 Endothelial Progenitor Cells in Cardiovascular Disorders
JF Journal of the American College of Cardiology
FD American College of Cardiology
SP 741
OP 752
DO 10.1016/j.jacc.2006.09.050
VO 49
IS 7
A1 Shantsila, Eduard
A1 Watson, Timothy
A1 Lip, Gregory Y.H.
YR 2007
UL http://www.onlinejacc.org/content/49/7/741.abstract
AB Endothelial Progenitor Cells in Cardiovascular DisordersEduard Shantsila, Timothy Watson, Gregory Y. H. LipBecause mature endothelial cells possess limited regenerative capacity, there is much interest in circulating endothelial precursor cells (EPCs). It has been suggested that these cells may play role in maintenance of endothelial integrity and take part in angiogenesis, giving the hope of new treatment opportunities. There is accumulating evidence for reduced availability and impaired EPC function in the presence of both cardiovascular disease and associated comorbid risk factors. The goal of this review paper is to provide an overview of data relevant to the clinical role of EPCs and perspectives for treatment of cardiovascular disorders.The important role of the vascular endothelium in cardiovascular health is increasingly recognized. However, mature endothelial cells possess limited regenerative capacity. There is therefore much interest in circulating endothelial progenitor cells (EPCs) among the scientific community, especially into their purported role in maintenance of endothelial integrity and function, as well as postnatal neovascularization. It has been suggested that these cells might not only be responsible for the continuous recovery of the endothelium after injury/damage, but also might take part in angiogenesis, giving the hope of new treatment opportunities. Indeed, there is accumulating evidence showing reduced availability and impaired EPC function in the presence of both cardiovascular disease and associated comorbid risk factors. Thus, many studies into the potential for use of EPCs in the clinical setting are being undertaken. The goal of this review article is to provide an overview of data relevant to the clinical role of EPCs and perspectives for treatment of cardiovascular disorders.