Recommendation for Mechanical Prosthetic Valve Thrombosis Diagnosis and Follow-Up

CORLOERecommendationComment/Rationale
IB-NRUrgent evaluation with multimodality imaging is indicated in patients with suspected mechanical prosthetic valve thrombosis to assess valvular function, leaflet motion, and the presence and extent of thrombus (216–222).MODIFIED: LOE updated to B-NR. Multiple recommendations for imaging in patients with suspected mechanical prosthetic valve thrombosis were combined into a single recommendation. Multimodality imaging with transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), fluoroscopy, and/or computed tomography (CT) scanning may be more effective than one imaging modality alone in detecting and characterizing valve thrombosis. Different imaging modalities are necessary because valve function, leaflet motion, and extent of thrombus should all be evaluated.
See Online Data Supplement 7.
Obstruction of mechanical prosthetic heart valves may be caused by thrombus formation, pannus ingrowth, or a combination of both (216). The presentation can vary from mild dyspnea to severe acute pulmonary edema. Urgent diagnosis, evaluation, and therapy are indicated because rapid deterioration can occur if there is thrombus causing malfunction of leaflet opening. The examination may demonstrate a stenotic murmur and muffled closing clicks, and further diagnostic evaluation is required. TTE and/or TEE should be performed to examine valve function and the status of the left ventricle (216). Leaflet motion should be visualized with TEE (particularly for a mitral prosthesis) or with CT or fluoroscopy (for an aortic prosthesis) (217–223). Prolonged periods of observation under fluoroscopy or TEE may be required to diagnose intermittent obstruction. The presence and quantification of thrombus should be evaluated by either TEE or CT (217,223). Differentiation of valve dysfunction due to thrombus versus fibrous tissue ingrowth (pannus) is challenging because the clinical presentations are similar. Thrombus is more likely with a history of inadequate anticoagulation, a more acute onset of valve dysfunction, and a shorter time between surgery and symptoms. Mechanical prosthetic valve thrombosis is diagnosed by an abnormally elevated gradient across the prosthesis, with either limited leaflet motion or attached mobile densities consistent with thrombus, or both. Vegetations from IE must be excluded. If obstruction is present with normal leaflet motion and no thrombus, either patient–prosthesis mismatch or pannus formation is present (or both). Thrombus formation on the valve in the absence of obstruction can also occur and is associated with an increased risk of embolic events.