Available Reversal Agents and Suggested Use
| Reversal Agent | Vitamin K Antagonists (Warfarin) | Factor IIa Inhibitor (Dabigatran) | Factor Xa Inhibitor (Apixaban, Edoxaban and Rivaroxaban) |
|---|---|---|---|
| 4F-PCC (56) | First line | Second line | First line |
| aPCC | Not indicated | Second line | Second line |
| Idarucizumab | Not indicated | First line | Not indicated |
| Plasma | If 4-PCC is unavailable | Not indicated | Not indicated |
4F-PCC = 4-factor prothrombin complex concentrate; aPCC = activated prothrombin complex concentrate.