Table 5

Available Reversal Agents and Suggested Use

Reversal AgentVitamin K Antagonists (Warfarin)Factor IIa Inhibitor (Dabigatran)Factor Xa Inhibitor (Apixaban, Edoxaban and Rivaroxaban)
4F-PCC (56)First lineSecond lineFirst line
aPCCNot indicatedSecond lineSecond line
IdarucizumabNot indicatedFirst lineNot indicated
PlasmaIf 4-PCC is unavailableNot indicatedNot indicated

4F-PCC = 4-factor prothrombin complex concentrate; aPCC = activated prothrombin complex concentrate.