Table 2

Guideline-Recommended Indications for ARNI and Ivabradine Use

Indications for Use of an ARNI
  • HFrEF (EF ≤40%)

  • NYHA class II or III HF

Indications for Use of Ivabradine
  • HFrEF (EF ≤35%)

  • On maximum tolerated doses of beta blocker

  • Sinus rhythm with a resting heart rate ≥70 bpm

  • NYHA class II or III HF

ARNI = angiotensin receptor-neprilysin inhibitor; bpm = beats per minute; EF = ejection fraction; HF = heart failure; HFrEF = heart failure with reduced ejection fraction; NYHA = New York Heart Association.