Table 3

Recommended Starting Dose of Sacubitril/Valsartan

PopulationInitial Dose
High-dose ACEI
> Enalapril 10 mg total daily dose or therapeutically equivalent dose of another ACEI
49/51 mg twice daily
High-dose ARB
> Valsartan 160 mg total daily dose or therapeutically equivalent dose of another ARB
Low or medium dose ACEI
≤ Enalapril 10 mg total daily dose or therapeutically equivalent dose of another ACEI
24/26 mg twice daily
Low or medium dose ARB
≤ Valsartan 160 mg total daily dose or therapeutically equivalent dose of another ARB
ACEI/ARB naïve
Severe renal impairment (eGFR <30 mL/min/1.73 m2)
Moderate hepatic impairment (Child-Pugh Class B)
Elderly (age ≥75 years)

ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; eGFR = estimated glomerular filtration rate.

  • See page 8.

  • This population was not studied in PARADIGM HF.