Table 3

Recommended Starting Dose of Sacubitril/Valsartan

PopulationInitial Dose
Moderate- or high-dose ACEI
Equivalent of enalapril ≥10 mg twice daily
49/51 mg twice daily
Moderate- or high-dose ARB
Equivalent of valsartan ≥80 mg twice daily
Low dose ACEI
Equivalent of <10 mg of enalapril twice daily
24/26 mg twice daily
Low dose ARB
Equivalent of valsartan ≤80 mg twice daily
ACEI/ARB naïve
Severe renal impairment (eGFR <30 mL/min/1.73 m2)
Moderate hepatic impairment (Child-Pugh Class B)
Elderly (age ≥75 years)

ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; eGFR = estimated glomerular filtration rate.

  • See page 8.

  • This population was not studied in PARADIGM HF.