Table 1

Complications of ECMO

Lower Extremity IschemiaFasciotomyLower Extremity AmputationBleedStrokeNeurologicAcute Kidney InsufficiencyRequiring Renal Replacement TherapySystemic InfectionRe-thoracotomy for bleed or tamponade
Reported Rate Min, Max, %3, 334, 211, 139, 641, 136, 5030, 8714, 8715, 908, 87
Cumulative Rate106/80437/45411/277167/58363/962181/1022158/343707/1370279/740398/820
Number of Studies137586961396
Cochran's Q38.17.884.9062.620.850.024.392.479.8132
P Value Heterogeneity<0.01Not SignificantNot Significant<0.01<0.01<0.01<0.01<0.01<0.01<0.01
I2, %68.523.918.388.876.083.379.487.090.096.2
Pooled Estimate Rate, %11.77.033.1228.86.2615.246.042.934.939.8
95% Confidence Interval, %7.63–15.84.00–10.10.39–5.8617.4–40.32.97–9.569.12–21.430.7–61.332.5–53.422.0–47.817.8–61.8