Table 3

Clinical Outcomes in Men and Women With HFrEF

Total EventsEvents per 100 Person-Years (95% CI)Women vs. Men
Women (n = 3,357)Men (n = 12,058)Women (n = 3,357)Men (n = 12,058)Unadjusted HR (95% CI) p ValueAdjusted HR (95% CI) p Value
Primary composite outcome808 (24.1)3,592 (29.8)9.88 (9.22–10.59)12.52 (12.12–12.94)0.79 (0.73–0.85)
<0.001
0.75 (0.69–0.81)
<0.001
First hospitalization for HF460 (13.7)2,059 (17.1)5.63 (5.13–6.16)7.18 (6.87–7.50)0.81 (0.74–0.90)
<0.001
0.80 (0.72–0.89)
<0.001
CV death508 (15.1)2,364 (19.6)5.74 (5.27–6.27)7.56 (7.26–7.87)0.74 (0.67–0.81)
<0.001
0.70 (0.63–0.77)
<0.001
 Sudden death196 (5.8)1,022 (8.5)2.22 (1.93–2.55)3.27 (3.07–3.47)0.67 (0.57–0.78)
<0.001
0.65 (0.56–0.76)
<0.001
 Pump failure death119 (3.5)616 (5.1)1.35 (1.12–1.61)1.97 (1.82–2.13)0.70 (0.57–0.85)
<0.001
0.67 (0.55–0.82)
<0.001
Non-CV death93 (2.8)476 (3.9)1.05 (0.86–1.29)1.52 (1.39–1.66)0.71 (0.57–0.89)
0.003
0.66 (0.52–0.83)
<0.001
All-cause death601 (17.9)2,840 (23.6)6.80 (6.27–7.36)9.08 (8.75–9.42)0.73 (0.67–0.80)
<0.001
0.68 (0.62–0.74)
<0.001
Fatal/nonfatal MI94 (2.8)412 (3.4)1.08 (0.88–1.32)1.33 (1.21–1.47)0.86 (0.69–1.08)
0.186
0.79 (0.63–1.00)
0.048
Fatal/nonfatal stroke134 (4.0)368 (3.1)1.54 (1.30–1.82)1.19 (1.08–1.32)1.31 (1.07–1.59)
0.008
1.22 (0.99–1.50)
0.062

Values are n (%), unless otherwise indicated. All outcomes have been adjusted for randomized treatment and region at baseline. Adjusted model has been adjusted for age, heart rate, systolic blood pressure, NT-proBNP, BMI, NYHA functional class, LVEF, and eGFR. All outcomes were tested for competing risks of all-cause and noncardiovascular (non-CV) death. Sudden death was tested for competing risk of all nonsudden deaths and pump failure death for all non–pump failure deaths. Non-CV death was tested for competing risk of CV death.

Abbreviations as in Table 2.

  • Additional adjusted for previous heart failure hospitalization.